NEW 2021 SAO PAULO STUDY . BRAZIL.
[url] https://www.researchsquare.com/article/rs-428174/v1 [/url]
[url] https://assets.researchsquare.com/files/rs-428174/v1/31ad6e9f-c751-4454-8ecf-cad9ac2cf667.pdf [/url]
Genetic ancestry of patients with colorectal lesions. The genetic ancestry component was obtained for 80 patients (91.9%) included in the study. The results indicated a high admixture and heterogeneity of the ancestry proportion of Brazilian samples, with the mean of ancestral proportions as follow: 73% (SD = 23.6%) for EUR, 11.3% (SD = 13.2%) for AFR, 9.1% (SD = 18.0%) for EAS and 6.6% (SD = 7.9%) for NAM (Fig. 3). We further compared the average genetic ancestry according to the lesion type, but no signicant association was found (Supplementary Table S5). According to mutation status, patients with higher mean of African ancestry harbored fewer alterations in CTNNB1 (p = 0.043) (Supplementary Table S6).
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